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Does one dose of psilocybin rewire the brain?

Explore the papers behind each claim and the reasons those claims are connected. These are source links and editorial assessments; proposed interpretations remain questions.

10 source papers · 13 claims · 9 relationships
Synthesis updated

Showing 10 of 10 papers and 13 of 13 claims

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Selected Claim 1. In healthy volunteers, a single 25 mg dose left enduring functional brain changes “largely absent” one month later, though some diffusion-imaging and network-modularity signals persisted; what lasted was mainly psychological: well-being and insight.

Paper cited for claimEditorial relationshipPosed question
Source papersClaims in this synthesisLyons 2026Daws 2022Jiang 2026Nardou 2023Novelli 2025Carhart-Harris 2021Goodwin 2022Shao 2021Siegel 2024Johansen 20261Healthy volunteers2Depression patients3Depression patients4Mice5Mice6Cross-cutting7Healthy volunteers8Depression patients9Depression patients10Mice11Humans12Humans13Healthy volunteers

Position and line length are for readability. They do not measure similarity, effect size or certainty. Paper-to-paper citations are not shown.

Browse as a list · 13 claims
  1. Lyons 2026

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  2. Daws 2022

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  3. Daws 2022

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  4. Jiang 2026

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  5. Nardou 2023

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  6. Nardou 2023, Lyons 2026, Shao 2021

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  7. Siegel 2024

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  8. Goodwin 2022

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  9. Carhart-Harris 2021

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  10. Shao 2021

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  11. Lyons 2026, Daws 2022, Carhart-Harris 2021

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  12. Novelli 2025

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  13. Johansen 2026

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What is included, and when it changes

The map follows the published synthesis. A new discovery enters the map only when its source and claim relationships are incorporated into a versioned update. Line length is a layout choice, not an evidence score. Semantic similarity and paper-to-paper citation networks are not included in this version.

Latest saved discovery scan: . It contains 521 discovered candidates. Screening status is not recorded in this snapshot. Discovered candidates are not automatically included as evidence.

This scan used 5 seed papers; the current synthesis specifies 10. Its discovery counts do not describe complete coverage of the current synthesis.

Editorial assessment is not independent scientific validation. Review status and limitations remain attached to the full claims.

A Violema evidence system. Explore the method

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